DMT stands for N, N-Dimethyltryptamine. It is a potent psychedelic drug, with serotonergic impacts on our brains, that can result in a quick and intense psychedelic experience often referred to as a ‘DMT trip’. It is a DMT experience is usually characterized by hallucinations of the visual, often being associated with powerful entities and is usually associated with deeper meaning. This experience that is meaningful can be described as a “DMT breakthrough.”. When it’s used as a leisure medication, DMT can be smoked or snorted or injecting in its crystal form.
The DMT molecules are structurally identical to other psychedelic tryptamines such as 5-MeO DMT, 4-AcO DMT and psilocybin. It allows it to attach to serotonin receptors, causing psychedelic effects.
DMT can be found naturally in a variety of plants and has been used for centuries as the psychoactive component in ayahuasca. Ayahuasca is a strong hallucinogenic drink that is considered to be an important component of shamanic traditions in the Upper as well as the Lower Amazon.
There is currently no evidence that supports an endogenous DMT production by humans. and specifically, whether DMT is created in the brain.
What exactly does DMT look like and how does it work?
DMT can be found in different types, that work for different consumption methods and alter the length that you experience. Pure DMT is an crystalline white powder or solid, but it is most often found as a yellow-pink material or solid. It is also available in herbal blends called ‘changa’.
The smoke (DMT): DMT powder can be smoked in bongs or pipes or vaporized through vape pens. Freebase DMT is generally linked to smoking.
Smoked (Changa): Changa is an herb blend that includes both a DMT-containing extract and monoamine oxide inhibitor (MAOI)-containing extracts from plants. Its combination with DMT and a MAOI is built upon the chemical principle of ayahuasca in which the addition a MAOI will prolong the journey. Changa can be smoked in pipe, joint bong, or even vaporized using the vape pen.
Injected: DMT must be injected in its salt form (DMT fumarate).
Ingestion/Orally: Consumed orally in the form of ayahuasca.
While DMT occurs naturally throughout plants and animals, it may also be chemically synthesized, creating DMT in its salt or base form. The term “freebase DMT is used to describe DMT in its pure alkaloidal form , which is insoluble in water, whilst ‘DMT fumarate’ refers to the salt form and is water soluble.
What is the way DMT perform as a medication in the brain and body?
DMT is a psychedelic tryptamine. It’s an indole alkaloid, and has an atomic structure similar to the neurotransmitter serotonin. This similarity in structure between DMT and serotonin permits it to be bound to serotonin receptors. Specifically, DMT acts as an agonist of the 5-HT2A receptor, whereby it binds and stimulates an response. It is believed that 5-HT2A receptor agonism has an essential role with regard to the hallucinogenic effect of DMT. The 5-HT2A receptor is associated with a variety of other psychedelics that are considered classic, including psilocybin and LSD as a result, these psychedelics are often called serotonergic psychedelics.
What is the effect of DMT?
Psychological impacts
DMT is highly effective and its effects can be observed around 2-5 minutes after consumption, and last for around 15 minutes. Despite its short-lived effects, DMT is known as one of the most powerful psychoactive substances. The subjective effects of DMT can be significant but they may differ depending on the dose. They include:
Inducing intense visual changes and hallucinations, particularly colourful and geometric shapes
Profound spiritual or mystical experiences
A variety of moods and emotional states, including joy, calm, fear and anxiety
Perceived encounters between external entities, which are often described as an elflike appearance.
Changed sense of time and place
Feelings of depersonalisation or experiences outside of the body
Potential auditory hallucinations
The evocation of powerful memories
Physiological effects
DMT is known to have low toxicity and is easily processed within the body. However, there are some physiological implications and associated risks to take note of. These include elevated blood pressure and an increased heart rate, which are particularly risky for those with heart diseases. The diminished motor and cognitive functioning poses a risk to your personal safety risk and presents further reasons to consider DMT to be consumed in a safe setting, with a sober and sane sitter. It should be noted that at high doses there are some reports of respiratory effects, seizures and Comas.
Does DMT have any medical uses?
DMT and its consumption as ayahuasca, has a long and storied history of traditional use as a medicine for diverse indigenous tribes of the Lower and Upper Amazon. Ayahuasca’s potential to be a therapeutic agent as a therapeutic tool for psychotherapy has attracted a lot of scientific interest. In addition, several clinical trials have reported beneficial effects in the treatment of depression and addiction.
The growing mainstream appreciation for the potential therapeutic value of the ayahuasca (DMT-containing beverage) and other classical psychedelics has led to increased research as to whether DMT has therapeutic properties. The results of scientific studies have shown that there are similarities with DMT and psilocybin. DMT is capable of generating a comparable mystical experience to that of psilocybin. It is believed that psilocybin affects brain activity and allows that the brain’s activity to be reset. So, recent evidence suggests that DMT can cause changes in the brain activity of humans may be beneficial. These similarities suggest that DMT could have the same therapeutic potential to psilocybin in treating mental disorders like depression and anxiety.
Is DMT safe? What is the best way to make sure the risks can be minimized or avoided?
DMT is a powerful psychedelic drug and, as in all other drugs it is essential that you are aware for both the psychological and physiological risks associated with the use of DMT.
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DMT produces a highly potent psychedelic experience consisting of intense visual alterations and hallucinations along with changes in mood and mood. The intensity of the experience can be emotionally stressful for some , and can trigger states of panic, anxiety and anxiety. For some , DMT creates an experience out of body or depersonalisation. It can be an overwhelming experience. Like all psychedelics the risks to your mental health can be minimized through’set and setting’. It is important to ensure that your mental state is secure and well-prepared as well as that the environment is safe and uplifting. Sober sitting is an important safety measure to protect yourself from the psychological damage.
Learn more about DMT harm reduction by visiting the harm reduction advice section.
Are there medical conditions that could make DMT more risky?
As with other psychedelics those with a history of mental health problems (such as psychosis, schizophrenia as well as bipolar disorder) could increase the chance of experiencing a painful experience. Additionally, there is the risk DMT can exacerbate the symptoms. There is not enough knowledge about the potential risks associated with use of psychedelics in those who have pre-existing mental health issues.
It is important to know that DMT can affect the serotonin-producing system and shouldn’t be taken in consumption alongside other medications that change the structure of the serotonin. This could lead to an illness that could be life-threatening, known as serotonin syndrome. This can include antidepressants as well as selective serotonin reuptake inhibitors (SSRIs).
The following prescription drugs carry an associated risk
SSRIs
Antipsychotics (although many will also block the actions of DMT)
Opioids, particularly tramadol, are opioids.
Antihypertensives
Central nervous system depressants
Vasodilators
Can DMT be combined with other drugs?
DMT should not be mixed alongside alcohol, or any other substances and having a better understanding of the effects and mechanism can provide an understanding of the dangers that come with mixing it with other drugs.
Some of the most effective drug combinations are as follows:
DMT is not recommended to be mixed with tramadol due to the risk of seizure hazard.
DMT should not be mixed with other stimulants like cocaine or amphetamines
DMT shouldn’t be mixed with cannabis.
DMT is a potent psychoactive and mixing it into other hallucinogens can increase the chance of making the trip more intense
DMT is not recommended to be mixed with recreationally prescribed drugs that are known to potentially cause interactions with DMT. This includes all the drugs that are listed above.
Is DMT addictive?
DMT, along with other psychedelics of the past, is not addictive. However, tolerance can develop after repeated use, and you need to use a higher dose to achieve the same effect.
DMT harm reduction advice
DMT is a powerful psychedelic that can give you an immediate and intense hallucinogenic experience. Informed harm reduction advice can assist in reducing some of the potential risks.
Being educated and prepared
It is vital to thoroughly educate yourself about the potential health risks and interactions between drugs and DMT. It is essential to ensure that the correct form and method of consumption is used and the right dose. The particularly powerful nature of DMT is why it is essential that enough preparation is made. This involves being aware of the physical and mental consequences that DMT can cause. Preparation is also linked to the person’s mindset.
Set and setting
‘Set’ refers to a individual’s mind-set, including their mood, thoughts , and expectations. This can have a significant influence on the experience of the trip and therefore it is advised that DMT should only be consumed when one is at peace and in a stable state of mind. “Setting” refers the setting and social environment that the drug is consumed. DMT is best consumed in a safe and calm surroundings, due to the intensity of the journey and the possible motor impairments.
Sitter
A sober sitter is particularly advised with DMT. The sitter will provide comfort as well as support throughout and following the excursion. The stability of the person who is seated is crucial and can give assurance and guidance during any confusing or overwhelming situations.
DMT myths and misunderstandings
Do human brains make DMT?
There has been a lot of debate about the possibility that DMT is made inside the human brain. A large portion of the debate has focused on the pineal gland, which is a tiny organ in the centre of the brain, which has been widely believed by many as the primary source of DMT. However, currently scientific evidence to support this theory remains very limited.
There are trace amounts of DMT in human blood and urine suggesting the creation of DMT in the human body. Even though a study recently revealed DMT in the pineal gland from rats has been any evidence of this being present in the brain’s pineal area of the human brain. A subsequent study revealed that DMT continues to be produced in the brains of rats following the being removed from the pineal gland creating further controversy in the debate over which gland in the brain is the main source of DMT. Understanding endogenous DMT production in the human body and the potential role it plays in physiology is an unexplored area and extensive further studies are required.
Are DMT and 5-MeO-DMT the same?
5-MeO-DMT stands for 5-Methoxy-N,N-Dimethyltryptamine. Although they might look similar, and have similar chemical structures, they create distinct experiences and should not be confused.