The NMN, also known as nicotinamide mononucleo an organic molecule that is found throughout all living organisms. It is a key ingredient in the production of NAD+, which is a crucial coenzyme which is involved in more than 400 metabolic reactions within the human body.
Although there aren’t many studies that have examined the effects of NMN supplements on human beings, research conducted in animals has demonstrated numerous NMN health benefits for rodents as well as other species of animals.
Animal studies have shown that NMN can boost fertility as well as memory cognition, energy metabolism mitochondrial function, and fertility. It is also able to aid in the treatment of obesity, assist with DNA repair, extend the life of the health of stem cells and decrease the risk of developing heart disease.
Studies on humans have not revealed any adverse consequences of this supplement and daily doses of up 500 mg is to be safe for humans.
If you’ve ever spent a significant amount of time researching supplements that could improve your health, speed up the process of ageing and make you live longer, you’ve likely encountered NMN. The supplement was formulated due to doctor. David Sinclair, a genetics professor at Harvard University and one of the top experts in the field of epigenetics and aging. Today, biohackersand people who are interested in health and wellness as well as regular folks supplement your diet with NMN with the hope that it can help them keep their youthfulness as long as they can. However, does the supplement perform as promised or is it simply an unproven fad with no scientific evidence to support it? We discuss this issue more in detail in our post.
What’s NMN?
The NMN, also known as nicotinamide mononucleo is a ribonucleotide natural molecule that is found in all living things including humans. The molecule is comprised of three groups: ribose the phosphate, and nicotinamide. NMN is vital to the life of an organism as it is an essential precursor for NAD+, also known as nicotinamide adenine dinucleotide. NAD+ is among the most vital coenzymes found in the body, enabling enzymes to catalyze a range of reactions. For example, NAD+ is essential to repair DNA and mitochondria function, which generates energy for the whole body.
The organism cannot exist when enzymes fail to initiate the necessary reactions. This is the reason it is essential for the body to have an adequate supply of coenzymes as well as their precursors. Unfortunately, as we get older and get older, the amount of NAD+ in our bodies diminishes and this results in the development of various diseases. But it is possible to delay or end dangers of the decline in NAD+ by replenishing levels of this coenzyme inside our bodies.
Why should I take NMN?
While it seems logical to just use NADplus supplements, the isn’t very effective as the coenzyme doesn’t pass through cell membranes before entering cells. This means that NAD+ supplements wouldn’t have any impact on the processes of cells or metabolism. The best option is to consume NAD+ precursors. NMN is the most similar NAD+ precursor to this chain reaction needed for the synthesis of the essential coenzyme. When taken orally NMN is rapidly absorbed by the body, which then transforms to NAD+. For instance, researchers discovered increased concentrations of NAD+ in mice’s livers within just 15 minutes.
As we’ve mentioned the body converts NMN to NAD+ which is a coenzyme that is essential to hundreds of metabolic processes in the body. Therefore, it’s not a surprise that NMN supplements can have an impact on a variety of organs and processes within the body. Although the majority of studies on supplements with NMN to date have been conducted on animals The results are positive. But, anyone who is who is considering taking NMN should be aware that scientists have to conduct more human studies in order to establish a definitive opinion on the safety and efficacy for NMN supplementation for human beings. In this regard below are the most prominent instances of NMN benefits as of now:
NMN reduces the risk of developing heart disease.
The heart disease has been identified as the primary cause of death for people living in developed nations and taking measures to ensure your blood vessels and heart are healthy is vital in order to live an extended and healthy life. Researchers have discovered that NMN could decrease the risk of stiffening blood vessels, reduce oxidative stress and alter the expression of genes in rodents.
In contrast to other muscles you have it doesn’t receive no breaks or rest. It is a vital muscle that requires a significant amount of energy in order to function. Therefore, it requires massive quantities of NMN which can be converted to NAD+. It could aid in energy metabolism. This implies that NMN could help improve the health of your heart and its function.
NMN can increase the energy metabolism
One of the biggest issues that people experience as they get older is a decrease in mobility and strength. This happens in part due to the fact that our bodies cease to generate the same amount of energy as they did in earlier times that leads to an impairment in the muscle’s function. However, research studies on mice have demonstrated an extended NMN supplementation increased the animals’ energy metabolism with no any noticeable negative results. Therefore, NMN might be able to aid humans in maintaining their fitness levels in the later stages of their lives. But, human studies are required to prove the hypothesis.
NMN could help in reducing obesity
Obesity is yet another problem that people living in developed nations face. It’s not difficult to see that the best method to avoid and treat diseases related to obesity is to exercise regularly and eat a balanced diet, however, many are unable to make these changes , and they want to make use of other options too. Incredibly, studies on mice have revealed that NMN is a comparable effect on our bodies as restriction in calories. Should this result be found on humans, this could indicate that NMN is a feasible solution to improve the overall health and wellbeing that millions of individuals throughout the globe.
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NMN can aid in DNA repair
Although DNA mutation may sound terrifying, it’s actually something which happens to our bodies each and every day. Our DNA is continuously being damaged by the effects of mutagens like free radicals and ultraviolet light. Our cells are also prone to making mistakes while transcribing and replicating genetic material. Additionally, each time cells divide, telomeres which are DNA fragments that are located at the end of each of them, get shorter. The shortening of telomeres and DNA mutations are all factors that result in the development of disease and the overall aging process of the body.
Our bodies continually attempt in order to fix DNA damages and stabilize the telomeres by using sirtuin proteins. These proteins require NAD+ for their perform their functions, and numerous studies have revealed that mice who consumed NMN supplements had higher quantities of NAD+, as well as more active sirtuins, as well as stabilised the telomeres.
NMN boosts mitochondrial function
If there’s a thing everyone is aware of about mitochondria is that they’re the cells’ powerhouses that is, they transform the food we consume into energy for our cells. But mitochondria aren’t able to create the energy they need without NAD+. If mitochondria in cells don’t function, the cell goes out of existence. For instance, the dysfunction of mitochondria resulted from the lack of NAD+ levels in cell can be linked to a variety of neurological disorders like Alzheimer’s. Researchers have demonstrated that administering NMN supplementation to rodents has the ability to bring back mitochondrial function.
NMN has a positive impact on cognition and memory
One of the most significant problems that ageing brings is the decline in cognitive ability and memory performance. Although some individuals can remain alert and retain their memory even as they reach a certain age, many older people, unfortunately, notice that their brains be unable to function at the same speed that they did when they were younger. However, recent studies of NMN impacts on rodents have produced promising outcomes. According to the researchers mice treated with NMN had a boost in cognition, a boost in blood flow to the brain, as well as overall improvement in brain functioning.
NMN helps to preserve the health of stem cells
Stem cells are vital to any living organism since they enable our bodies to produce the new tissue, fix it and maintain our health. As our bodies age, the health that stem cells have diminishes and they cease to job at the same level as they did in the past. Numerous studies have proven that the increased quantities of NMN and NAD+ in the body are in a position to boost the health of stem cells as well as boost the body’s self-renewal as well as self-healing abilities.
NMN can have a positive impact on fertility and libido
A decline in libido as well as fertility levels is an unpleasant side effect of aging. It is interesting to note that many who regularly consume NMN supplements have noticed an increase in their libido. It’s crucial to keep in mind that this is merely speculation that isn’t supported by any research currently. There is however some scientific evidence that suggests this supplement may boost fertility, and even increase it in animals that are older.
NMN can prolong the lifespan
NMN has also been proven to prolong the life span of worms, mice, and yeast. It is possible that this is to be a synergetic effect with the other health benefits associated with this supplement.